BENZYLIDENESALICYLOYLHYDRAZINATO- N,O)TIN(IV)] (R = OCH3, Br, N(CH3)2) AND THEIR ANTI-INFLAMMATORY ACTIVITY

• Main Authors: N. V. Shmatkova, I. I. Seifullina, A. I. Aleksandrova, A. V. Polishchuk
• Format: Article
• Language: English
• Published: Odessa I. I. Mechnikov National University 2014-11-01
• Series: Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ
• Subjects: протизапальна активність; станум (IV); SnCl4; гідразони; координаційні сполуки
• Online Access: http://heraldchem.onu.edu.ua/article/view/31317

The complexes [SnCl4(2-OH-HB-4R-b)] ·CH3CN (R = 4-OCH3 (І), 4-Br(II)) were obtained by interaction of SnCl4 with salicyloylhydrazones 4–R- benzaldehydes (2-OH-HB-4R-b) in acetonitrile. The composition and structure (O(C=O)-N(CH=N) – the coordination of ligand’s amide form) were established by element analysis methods, conductometry, thermogravimetry and IR spectroscopy. It was studied the anti-inflammatory activity of (I, II) and previously synthesized, structurally characterized [SnCl4(2-OH-HB-4R-b∙H)] (R=N (CH3)2 (III) in model of aseptic carrageenan induced swelling, and it is shown that compound (II) demonstrates the highest activity.