The wiring diagram of a glomerular olfactory system

The wiring diagram of a glomerular olfactory system

The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a can...

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Main Authors: Matthew E Berck, Avinash Khandelwal, Lindsey Claus, Luis Hernandez-Nunez, Guangwei Si, Christopher J Tabone, Feng Li, James W Truman, Rick D Fetter, Matthieu Louis, Aravinthan DT Samuel, Albert Cardona
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
olfaction
neural circuits
Drosophila
electron microscopy
connectomics
Online Access:https://elifesciences.org/articles/14859
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spelling doaj-596f2169fc2b49abbec0101dc4d59ab52021-05-05T00:23:37ZengeLife Sciences Publications LtdeLife2050-084X2016-05-01510.7554/eLife.14859The wiring diagram of a glomerular olfactory systemMatthew E Berck0Avinash Khandelwal1Lindsey Claus2Luis Hernandez-Nunez3Guangwei Si4Christopher J Tabone5https://orcid.org/0000-0001-8746-0680Feng Li6James W Truman7Rick D Fetter8Matthieu Louis9https://orcid.org/0000-0002-2267-0262Aravinthan DT Samuel10Albert Cardona11https://orcid.org/0000-0003-4941-6536Department of Physics, Harvard University, Cambridge, United States; Center for Brain Science, Harvard University, Cambridge, United StatesEMBL-CRG Systems Biology Program, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, SpainDepartment of Physics, Harvard University, Cambridge, United States; Center for Brain Science, Harvard University, Cambridge, United StatesDepartment of Physics, Harvard University, Cambridge, United States; Center for Brain Science, Harvard University, Cambridge, United StatesDepartment of Physics, Harvard University, Cambridge, United States; Center for Brain Science, Harvard University, Cambridge, United StatesDepartment of Physics, Harvard University, Cambridge, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesEMBL-CRG Systems Biology Program, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, SpainDepartment of Physics, Harvard University, Cambridge, United States; Center for Brain Science, Harvard University, Cambridge, United StatesJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United StatesThe sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior.https://elifesciences.org/articles/14859olfactionneural circuitsDrosophilaelectron microscopyconnectomics
collection DOAJ
language English
format Article
sources DOAJ
author Matthew E Berck
Avinash Khandelwal
Lindsey Claus
Luis Hernandez-Nunez
Guangwei Si
Christopher J Tabone
Feng Li
James W Truman
Rick D Fetter
Matthieu Louis
Aravinthan DT Samuel
Albert Cardona
spellingShingle Matthew E Berck
Avinash Khandelwal
Lindsey Claus
Luis Hernandez-Nunez
Guangwei Si
Christopher J Tabone
Feng Li
James W Truman
Rick D Fetter
Matthieu Louis
Aravinthan DT Samuel
Albert Cardona
The wiring diagram of a glomerular olfactory system
eLife
olfaction
neural circuits
Drosophila
electron microscopy
connectomics
author_facet Matthew E Berck
Avinash Khandelwal
Lindsey Claus
Luis Hernandez-Nunez
Guangwei Si
Christopher J Tabone
Feng Li
James W Truman
Rick D Fetter
Matthieu Louis
Aravinthan DT Samuel
Albert Cardona
author_sort Matthew E Berck
title The wiring diagram of a glomerular olfactory system
title_short The wiring diagram of a glomerular olfactory system
title_full The wiring diagram of a glomerular olfactory system
title_fullStr The wiring diagram of a glomerular olfactory system
title_full_unstemmed The wiring diagram of a glomerular olfactory system
title_sort wiring diagram of a glomerular olfactory system
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2016-05-01
description The sense of smell enables animals to react to long-distance cues according to learned and innate valences. Here, we have mapped with electron microscopy the complete wiring diagram of the Drosophila larval antennal lobe, an olfactory neuropil similar to the vertebrate olfactory bulb. We found a canonical circuit with uniglomerular projection neurons (uPNs) relaying gain-controlled ORN activity to the mushroom body and the lateral horn. A second, parallel circuit with multiglomerular projection neurons (mPNs) and hierarchically connected local neurons (LNs) selectively integrates multiple ORN signals already at the first synapse. LN-LN synaptic connections putatively implement a bistable gain control mechanism that either computes odor saliency through panglomerular inhibition, or allows some glomeruli to respond to faint aversive odors in the presence of strong appetitive odors. This complete wiring diagram will support experimental and theoretical studies towards bridging the gap between circuits and behavior.
topic olfaction
neural circuits
Drosophila
electron microscopy
connectomics
url https://elifesciences.org/articles/14859
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