The second chance story of HIV-1 DNA: Unintegrated? Not a problem!

<p>Abstract</p> <p>Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence...

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Main Author: Wu Yuntao
Format: Article
Language:English
Published: BMC 2008-07-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/5/1/61
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spelling doaj-596b5a4729ee48e097e6f7f99c02a7de2020-11-25T01:58:20ZengBMCRetrovirology1742-46902008-07-01516110.1186/1742-4690-5-61The second chance story of HIV-1 DNA: Unintegrated? Not a problem!Wu Yuntao<p>Abstract</p> <p>Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector.</p> http://www.retrovirology.com/content/5/1/61
collection DOAJ
language English
format Article
sources DOAJ
author Wu Yuntao
spellingShingle Wu Yuntao
The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
Retrovirology
author_facet Wu Yuntao
author_sort Wu Yuntao
title The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
title_short The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
title_full The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
title_fullStr The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
title_full_unstemmed The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
title_sort second chance story of hiv-1 dna: unintegrated? not a problem!
publisher BMC
series Retrovirology
issn 1742-4690
publishDate 2008-07-01
description <p>Abstract</p> <p>Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector.</p>
url http://www.retrovirology.com/content/5/1/61
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