The second chance story of HIV-1 DNA: Unintegrated? Not a problem!
<p>Abstract</p> <p>Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence...
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| Format: | Article |
| Language: | English |
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BMC
2008-07-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/5/1/61 |
| Summary: | <p>Abstract</p> <p>Accumulation of high levels of unintegrated viral DNA is a common feature of retroviral infection. It was recently discovered that coinfection of cells with integrated and unintegrated HIV-1 can result in complementation, allowing viral replication in the absence of integration. This new mode of HIV-1 replication has numerous implications for the function of unintegrated viral DNA and its application as a therapeutic vector.</p> |
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| ISSN: | 1742-4690 |