Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of <i>rac</i>-5β-Hydroxy-<span style="font-variant: small-caps">d</span>-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action

Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of <i>rac</i>-5β-Hydroxy-<span style="font-variant: small-caps">d</span>-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action

An efficient synthesis of <i>rac</i>-6-desmethyl-5β–hydroxy-<span style="font-variant: small-caps;">d</span>-secoartemisinin <b>2</b>, a tricyclic analog of <i>R</i>-(+)-artemisinin <b>1</b>, was accomplished and the racemate was...

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Bibliographic Details
Main Authors: Mohamed Jahan, Francisco Leon, Frank R. Fronczek, Khaled M. Elokely, John Rimoldi, Shabana I. Khan, Mitchell A. Avery
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
artemisinin
racemate
enantiomers
Mosher ester
diastereomers
<i>Plasmodium falciparum</i>
Online Access:https://www.mdpi.com/1420-3049/26/14/4163

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