The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

The Potential Roles of RNA N6-Methyladenosine in Urological Tumors

N6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m6A -binding prote...

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Main Authors: Yang Li, Yu-zheng Ge, Luwei Xu, Zheng Xu, Quanliang Dou, Ruipeng Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
N6-methyladenosine (m6A)
writers
erasers
readers
urological tumors
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.579919/full
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spelling doaj-595e6a4aa31947be8d481b898395561b2020-11-25T03:19:16ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-09-01810.3389/fcell.2020.579919579919The Potential Roles of RNA N6-Methyladenosine in Urological TumorsYang LiYu-zheng GeLuwei XuZheng XuQuanliang DouRuipeng JiaN6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m6A -binding proteins such as YTHDF1/2/3, IGF2BP1/2/3 and HNRNPA2B1 (readers). Emerging evidence suggests that m6A modification is significant for regulating many biological and cellular processes and participates in the pathological development of various diseases, including tumors. This article reviews recent studies on the biological function of m6A modification and the methylation modification of m6A in urological tumors.https://www.frontiersin.org/article/10.3389/fcell.2020.579919/fullN6-methyladenosine (m6A)writerserasersreadersurological tumors
collection DOAJ
language English
format Article
sources DOAJ
author Yang Li
Yu-zheng Ge
Luwei Xu
Zheng Xu
Quanliang Dou
Ruipeng Jia
spellingShingle Yang Li
Yu-zheng Ge
Luwei Xu
Zheng Xu
Quanliang Dou
Ruipeng Jia
The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
Frontiers in Cell and Developmental Biology
N6-methyladenosine (m6A)
writers
erasers
readers
urological tumors
author_facet Yang Li
Yu-zheng Ge
Luwei Xu
Zheng Xu
Quanliang Dou
Ruipeng Jia
author_sort Yang Li
title The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_short The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_full The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_fullStr The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_full_unstemmed The Potential Roles of RNA N6-Methyladenosine in Urological Tumors
title_sort potential roles of rna n6-methyladenosine in urological tumors
publisher Frontiers Media S.A.
series Frontiers in Cell and Developmental Biology
issn 2296-634X
publishDate 2020-09-01
description N6-methyladenosine (m6A) is regarded as the most abundant, prevalent and conserved internal mRNA modification in mammalian cells. M6A can be catalyzed by m6A methyltransferases METTL3, METTL14 and WTAP (writers), reverted by demethylases ALKBH5 and FTO (erasers), and recognized by m6A -binding proteins such as YTHDF1/2/3, IGF2BP1/2/3 and HNRNPA2B1 (readers). Emerging evidence suggests that m6A modification is significant for regulating many biological and cellular processes and participates in the pathological development of various diseases, including tumors. This article reviews recent studies on the biological function of m6A modification and the methylation modification of m6A in urological tumors.
topic N6-methyladenosine (m6A)
writers
erasers
readers
urological tumors
url https://www.frontiersin.org/article/10.3389/fcell.2020.579919/full
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