17<i>β</i>-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway

17<i>β</i>-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway

Apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that can be secreted, and recently suggested as new biomarker for vascular inflammation. However, the endogenous hormones for APE1/Ref-1 secretion and its underlying mechanisms are not defined. Here, the ef...

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Bibliographic Details
Main Authors: Yu-Ran Lee, Hee-Kyoung Joo, Eun-Ok Lee, Sungmin Kim, Hao Jin, Yeon-Hee Choi, Cuk-Seong Kim, Byeong-Hwa Jeon
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Biomedicines
Subjects:
apurinic/apyrimidinic endonuclease-1/redox factor-1
17β-estradiol
estrogen receptor
endothelial cells
calcium
exosome
Online Access:https://www.mdpi.com/2227-9059/9/8/1040

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