Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one

Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one

The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chrome...

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Main Authors: B. Lakshminarayanan, V. Rajamanickam, T. Subburaju, L. A. Pradeep Rajkumar
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:E-Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2010/184290
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spelling doaj-59505c24ac7d4d23860b3049a8fa9a6d2020-11-24T23:01:31ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102010-01-017238339010.1155/2010/184290Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-oneB. Lakshminarayanan0V. Rajamanickam1T. Subburaju2L. A. Pradeep Rajkumar3Karpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaArulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankoil-626190, IndiaKarpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaKarpagam College of Pharmacy, S.F.No:762, Othakkalmandapam, Coimbatore-641032, IndiaThe title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.http://dx.doi.org/10.1155/2010/184290
collection DOAJ
language English
format Article
sources DOAJ
author B. Lakshminarayanan
V. Rajamanickam
T. Subburaju
L. A. Pradeep Rajkumar
spellingShingle B. Lakshminarayanan
V. Rajamanickam
T. Subburaju
L. A. Pradeep Rajkumar
Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
E-Journal of Chemistry
author_facet B. Lakshminarayanan
V. Rajamanickam
T. Subburaju
L. A. Pradeep Rajkumar
author_sort B. Lakshminarayanan
title Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
title_short Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
title_full Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
title_fullStr Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
title_full_unstemmed Synthesis and Antimicrobial Activity of Some 3-(5-Phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
title_sort synthesis and antimicrobial activity of some 3-(5-phenyl-4,5-dihydro-1-substitutedpyrazol-3-yl) chromen-2-one
publisher Hindawi Limited
series E-Journal of Chemistry
issn 0973-4945
2090-9810
publishDate 2010-01-01
description The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.
url http://dx.doi.org/10.1155/2010/184290
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AT vrajamanickam synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one
AT tsubburaju synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one
AT lapradeeprajkumar synthesisandantimicrobialactivityofsome35phenyl45dihydro1substitutedpyrazol3ylchromen2one
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