Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes

<p>Abstract</p> <p>Background</p> <p>Activating <it>KRAS </it>mutations are important for cancer initiation and progression; and have recently been shown to cause primary resistance to therapies targeting the epidermal growth factor receptor. Therefore, stra...

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Bibliographic Details
Main Authors: Dang Duyen T, Cruz-Correa Marcia R, Washburn Joseph G, Johnson Craig, Chun Sang Y, Dang Long H
Format: Article
Language:English
Published: BMC 2010-11-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/293

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