Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in <i>Hamp</i> KO Mice

Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in <i>Hamp</i> KO Mice

Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes. In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin...

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Bibliographic Details
Main Authors: Xiaoyu Wang, Mingzhen Zhang, Regina R. Woloshun, Yang Yu, Jennifer K. Lee, Shireen R. L. Flores, Didier Merlin, James F. Collins
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Nutrients
Subjects:
hepcidin antimicrobial peptide
hereditary hemochromatosis
iron overload
divalent metal-ion transporter 1
<i>Slc11a2</i>
nanoparticles
Online Access:https://www.mdpi.com/2072-6643/13/5/1686

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