Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide

Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide

Abstract Background Chimeric antigen receptors (CARs) presented on T cell surfaces enable redirection of T cell specificity, which has enormous promise in antitumor therapy. However, excessive activity and poor control over such engineered T cells cause significant safety challenges, such as cytokin...

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Bibliographic Details
Main Authors: Erhao Zhang, Jieyi Gu, Jianpeng Xue, Chenyu Lin, Chen Liu, Mengwei Li, Jingchao Hao, Sarra Setrerrahmane, Xiaowei Chi, Weiyan Qi, Jialiang Hu, Hanmei Xu
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Hematology & Oncology
Subjects:
Cancer immunotherapy
Switchable dual-receptor CAR
K562 cell
HM-3
Bifunctional molecule
Online Access:http://link.springer.com/article/10.1186/s13045-018-0591-7

Internet

http://link.springer.com/article/10.1186/s13045-018-0591-7

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