3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor

3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor

The global spread of the novel coronavirus SARS-CoV-2 urgently requires discovery of effective therapeutics for the treatment of COVID-19. The spike (S) protein of SARS-CoV-2 plays a key role in receptor recognition, virus-cell membrane fusion and virus entry. Our previous studies have reported that...

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Bibliographic Details
Main Authors: Taizhen Liang, Jiayin Qiu, Xiaoge Niu, Qinhai Ma, Chenliang Zhou, Pei Chen, Qiao Zhang, Meiyun Chen, Zifeng Yang, Shuwen Liu, Lin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
SARS-CoV-2
3-hydroxyphthalic anhydride-modified chicken ovalbumin
spike
fusion inhibitor
angiotensin-converting enzyme 2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.603830/full

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