Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone

Synthesis of some potent immunomodulatory and anti-inflammatory metabolites by fungal transformation of anabolic steroid oxymetholone

<p>Abstract</p> <p>Background</p> <p>Biotransformation of organic compounds by using microbial whole cells provides an efficient approach to obtain novel analogues which are often difficult to synthesize chemically. In this manuscript, we report for the first time the m...

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Bibliographic Details
Main Authors: Khan Naik Tameen, Bibi Marium, Yousuf Sammer, Qureshi Izhar Husain, Atta-ur-Rahman, Al-Majid Abdullah Mohammad, Mesaik Muhammad Ahmed, Khalid Ahmed Shukralla, Sattar Samina A, Atia-tul-Wahab, Choudhary M Iqbal
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Chemistry Central Journal
Subjects:
Oxymetholone
Anabolic steroid
Biotransformation
<it>de novo</it> Hydroxylation
Immunomodulation
T-Cell proliferation inhibition
Anti-inflammation
Inhibition of reactive oxygen species production
3T3 Fibroblast cells
Online Access:http://journal.chemistrycentral.com/content/6/1/153

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