Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

The expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, and Huntington disease. PARK7 acti...

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Main Author:	Wook Jin
Format:	Article
Language:	English
Published:	MDPI AG 2020-04-01
Series:	Journal of Clinical Medicine
Subjects:	PARK7 (DJ-1) therapeutic target apoptosis redox sensor chemoresistance
Online Access:	https://www.mdpi.com/2077-0383/9/5/1256

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spelling	doaj-59374579316d4c7cb0d36b8a2e45cfed2020-11-25T03:25:35ZengMDPI AGJournal of Clinical Medicine2077-03832020-04-0191256125610.3390/jcm9051256Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer ProgressionWook Jin0Laboratory of Molecular Disease and Cell Regulation, Department of Biochemistry, School of Medicine, Gachon University, Incheon 406-840, KoreaThe expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, and Huntington disease. PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued proliferation, metastasis, recurrence, and resistance to chemotherapy. Additionally, secreted PARK7 has been identified as a high-risk factor for the pathogenesis and survival of various cancers. This review summarizes the current understanding of the correlation between the expression of PARK7 and tumor progression.https://www.mdpi.com/2077-0383/9/5/1256PARK7 (DJ-1)therapeutic targetapoptosisredox sensorchemoresistance
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wook Jin
spellingShingle	Wook Jin Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression Journal of Clinical Medicine PARK7 (DJ-1) therapeutic target apoptosis redox sensor chemoresistance
author_facet	Wook Jin
author_sort	Wook Jin
title	Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression
title_short	Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression
title_full	Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression
title_fullStr	Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression
title_full_unstemmed	Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression
title_sort	novel insights into park7 (dj-1), a potential anti-cancer therapeutic target, and implications for cancer progression
publisher	MDPI AG
series	Journal of Clinical Medicine
issn	2077-0383
publishDate	2020-04-01
description	The expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, and Huntington disease. PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued proliferation, metastasis, recurrence, and resistance to chemotherapy. Additionally, secreted PARK7 has been identified as a high-risk factor for the pathogenesis and survival of various cancers. This review summarizes the current understanding of the correlation between the expression of PARK7 and tumor progression.
topic	PARK7 (DJ-1) therapeutic target apoptosis redox sensor chemoresistance
url	https://www.mdpi.com/2077-0383/9/5/1256
work_keys_str_mv	AT wookjin novelinsightsintopark7dj1apotentialanticancertherapeutictargetandimplicationsforcancerprogression
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Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

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