MOLECULAR BIOLOGY OF HEPATITIS B VIRUS AND IMMUNOPATHOGENESIS OF CHRONIC VIRAL HEPATITIS B

• Main Authors: I. P. Balmasova, R. I. Sepiashvili, E. S. Malova
• Format: Article
• Language: Russian
• Published: Central Research Institute for Epidemiology 2016-04-01
• Series: Журнал микробиологии, эпидемиологии и иммунобиологии
• Subjects: hepatitis b virus (hbv); hbv replication; chronic hepatitis b; immunopathogenesis; t-lymphocyte subpopulations
• Online Access: https://microbiol.elpub.ru/jour/article/view/40

Hronic hepatitis B belongs to a category of socially significant diseases due to its wide abundance in the world and high frequency of unfavourable outcomes of this disease. Features of interaction of hepatitis B virus with human immune system, accompanying development of mechanisms of escape from immunological control, is the basis of development of chronic hepatitis B. Molecular-biological features of hepatitis B virus are the basis of the indicated mechanisms, and the content of this review is their examination. Herewith, stages of immunopathogenesis of this disease is the basis of characteristics of interaction of viral proteins with cells of immune system, and isolation of those is accepted in contemporary foreign literature.