Skin PAMPA: Application in practice

Skin PAMPA: Application in practice

Transdermal drug delivery has been growing extensively in the past decades, therefore new, reliable and cost-effective in vitro models were demanded to support the research and development on this field. Model membrane of PAMPA mimicking skin penetration was first described in 2006, but the need for...

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Main Authors: Bálint Sinkó, Gábor Vizserálek, Krisztina Takács-Novák
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2015-01-01
Series:ADMET and DMPK
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/150
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spelling doaj-5925ae0d73f846cea964df95c355ea952020-11-24T23:01:31ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182015-01-012419119810.5599/admet.2.4.150114Skin PAMPA: Application in practiceBálint Sinkó0Gábor Vizserálek1Krisztina Takács-Novák2SinkoLAB ScientificSemmelweis University, Department of Pharmaceutical ChemistrySemmelweis University, Department of Pharmaceutical ChemistryTransdermal drug delivery has been growing extensively in the past decades, therefore new, reliable and cost-effective in vitro models were demanded to support the research and development on this field. Model membrane of PAMPA mimicking skin penetration was first described in 2006, but the need for more bio-mimetic system has been arisen by new industrial tendencies and a bio-relevant system was published in 2012. Since its first publication Skin PAMPA has already been applied by several universities and industrial groups successfully and the first articles, podium and poster presentations have been appeared. The original Skin PAMPA model has been further developed in order to extend its application for formulations. Examples of liquid or semi-solid formulation projects and transdermal patch studies are available beside standard solution applications. The present review demonstrates the different approaches needed for various type of samples, provides examples of applications and practical conclusions for further improvement.http://pub.iapchem.org/ojs/index.php/admet/article/view/150
collection DOAJ
language English
format Article
sources DOAJ
author Bálint Sinkó
Gábor Vizserálek
Krisztina Takács-Novák
spellingShingle Bálint Sinkó
Gábor Vizserálek
Krisztina Takács-Novák
Skin PAMPA: Application in practice
ADMET and DMPK
author_facet Bálint Sinkó
Gábor Vizserálek
Krisztina Takács-Novák
author_sort Bálint Sinkó
title Skin PAMPA: Application in practice
title_short Skin PAMPA: Application in practice
title_full Skin PAMPA: Application in practice
title_fullStr Skin PAMPA: Application in practice
title_full_unstemmed Skin PAMPA: Application in practice
title_sort skin pampa: application in practice
publisher International Association of Physical Chemists (IAPC)
series ADMET and DMPK
issn 1848-7718
publishDate 2015-01-01
description Transdermal drug delivery has been growing extensively in the past decades, therefore new, reliable and cost-effective in vitro models were demanded to support the research and development on this field. Model membrane of PAMPA mimicking skin penetration was first described in 2006, but the need for more bio-mimetic system has been arisen by new industrial tendencies and a bio-relevant system was published in 2012. Since its first publication Skin PAMPA has already been applied by several universities and industrial groups successfully and the first articles, podium and poster presentations have been appeared. The original Skin PAMPA model has been further developed in order to extend its application for formulations. Examples of liquid or semi-solid formulation projects and transdermal patch studies are available beside standard solution applications. The present review demonstrates the different approaches needed for various type of samples, provides examples of applications and practical conclusions for further improvement.
url http://pub.iapchem.org/ojs/index.php/admet/article/view/150
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AT gaborvizseralek skinpampaapplicationinpractice
AT krisztinatakacsnovak skinpampaapplicationinpractice
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