Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels

Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K+ channels

Voltage-gated K+ (KV) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential therapeutic targets in many types of diseases. Pimaric acid (PiMA) is a unique opener of large conductance Ca2+-activated K+ channel. Here, we report that PiMA modulat...

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Bibliographic Details
Main Authors: Kazuho Sakamoto, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Katsuhiko Muraki, Yuji Imaizumi
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Voltage-gated K+ channel
K+ channel opener
Rosin acid
Channel gating
Ca2+-activated K+ channel
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300373

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