Teasing apart the cell death pathways in HIV pathogenesis
The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02077-2 |
| Summary: | The progressive loss of CD4 + T cells has been recognised as being central to HIV-1 pathogenesis, however a precise understanding of the underlying mechanisms and, consequently, improved therapies have yet to be achieved. Zhang et al. have recently shown in HIV-1 patients that the NLRP3 inflammasome pathway, which plays a key role in innate immunity, is a crucial mediator of the loss of CD4 + T cells. This advance could inform the development of innovative anti-HIV-1 therapies. |
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| ISSN: | 2399-3642 |