Costimulation blockade by combining CTLA4Ig with anti-CD40L mAb markedly inhibits the inflammatory response of experimental autoimmune myocarditis

Costimulation blockade by combining CTLA4Ig with anti-CD40L mAb markedly inhibits the inflammatory response of experimental autoimmune myocarditis

The aim of this study was to investigate the effect of costimulation blockade with cytotoxic T-lymphocyte-associated-antigen 4-immunoglobulin (CTLA4Ig) and anti-CD40L monoclonal antibody (anti-CD40L mAb) on an experimental autoimmune myocarditis (EAM) mouse model. Characteristics of myocardial tissu...

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Bibliographic Details
Main Authors: Qing-Quan Chen, Min Chen, Li-Hua Zhang, Yu Zeng, Liu Qi-Cai, Xiu-Lin Yang, Xu-Chen Lin
Format: Article
Language:English
Published: SAGE Publishing 2017-04-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X16686980

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