Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability

Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability

Hematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.

Bibliographic Details
Main Authors: Magdalena Leiva, Juan A. Quintana, José M. Ligos, Andrés Hidalgo
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10222
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spelling doaj-590357cb8e5242c5a6fe807145cf27d32021-05-11T11:14:22ZengNature Publishing GroupNature Communications2041-17232016-01-017111010.1038/ncomms10222Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availabilityMagdalena Leiva0Juan A. Quintana1José M. Ligos2Andrés Hidalgo3Area of Developmental and Cell Biology, Centro Nacional de Investigaciones CardiovascularesArea of Developmental and Cell Biology, Centro Nacional de Investigaciones CardiovascularesCellomics Unit, Centro Nacional de Investigaciones CardiovascularesArea of Developmental and Cell Biology, Centro Nacional de Investigaciones CardiovascularesHematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.https://doi.org/10.1038/ncomms10222
collection DOAJ
language English
format Article
sources DOAJ
author Magdalena Leiva
Juan A. Quintana
José M. Ligos
Andrés Hidalgo
spellingShingle Magdalena Leiva
Juan A. Quintana
José M. Ligos
Andrés Hidalgo
Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
Nature Communications
author_facet Magdalena Leiva
Juan A. Quintana
José M. Ligos
Andrés Hidalgo
author_sort Magdalena Leiva
title Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_short Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_full Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_fullStr Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_full_unstemmed Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability
title_sort haematopoietic esl-1 enables stem cell proliferation in the bone marrow by limiting tgfβ availability
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-01-01
description Hematopoietic stem and progenitor cell (HSPCs) proliferation is controlled by signals from the niche. Here, Leivaet al. show in vivoin mice that deletion of E-selectin ligand 1 causes quiescence of HSPCs and a reduction in niche size, which is mediated by changes of TGFß levels in the bone marrow.
url https://doi.org/10.1038/ncomms10222
work_keys_str_mv AT magdalenaleiva haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability
AT juanaquintana haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability
AT josemligos haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability
AT andreshidalgo haematopoieticesl1enablesstemcellproliferationinthebonemarrowbylimitingtgfbavailability
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