Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation
Precision editing with CRISPR-Cas9 often suffers from poor efficiency. Here the authors identify culture conditions and small molecules that synergize to promote homology-directed repair (HDR) in induced pluripotent stem (iPS) cells.
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16643-5 |