Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).

Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).

Skeletal muscle resistance to the key metabolic hormones, leptin and insulin, is an early defect in obesity. Suppressor of cytokine signaling 3 (SOCS3) is a major negative regulator of both leptin and insulin signaling, thereby implicating SOCS3 in the pathogenesis of obesity and associated metaboli...

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Bibliographic Details
Main Authors: Zhenggang Yang, Matthew Hulver, Ryan P McMillan, Lingzhi Cai, Erin E Kershaw, Liqing Yu, Bingzhong Xue, Hang Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3480378?pdf=render

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