Gene modification strategies for next-generation CAR T cells against solid cancers

Gene modification strategies for next-generation CAR T cells against solid cancers

Abstract Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies. However, CAR T therapy against solid tumors is less effective. Antigen targeting; an immunosuppre...

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Bibliographic Details
Main Authors: Yonggui Tian, Yilu Li, Yupei Shao, Yi Zhang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Hematology & Oncology
Subjects:
CAR T cells
Immunotherapy
Genetic engineering
Solid tumor
Online Access:http://link.springer.com/article/10.1186/s13045-020-00890-6

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