Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents

A new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl-3-(2-(tosyloxy)phenyl)propane-1,3-dione, N,N-dimethylformamide dimethyl acetal and hydrazine or hydroxylamine hydrochloride...

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Main Authors:	Babasaheb V. Kendre, Mahadev G. Landge, Sudhakar R. Bhusare
Format:	Article
Language:	English
Published:	Elsevier 2019-12-01
Series:	Arabian Journal of Chemistry
Online Access:	http://www.sciencedirect.com/science/article/pii/S1878535215000258

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spelling	doaj-58f745970a9f426caf68604c9a1e11e72020-11-25T01:37:09ZengElsevierArabian Journal of Chemistry1878-53522019-12-0112820912097Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agentsBabasaheb V. Kendre0Mahadev G. Landge1Sudhakar R. Bhusare2Corresponding author. Fax: +91 2452 242466.; Department of Chemistry, Dnyanopasak College, Parbhani 431401, MS, IndiaDepartment of Chemistry, Dnyanopasak College, Parbhani 431401, MS, IndiaDepartment of Chemistry, Dnyanopasak College, Parbhani 431401, MS, IndiaA new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl-3-(2-(tosyloxy)phenyl)propane-1,3-dione, N,N-dimethylformamide dimethyl acetal and hydrazine or hydroxylamine hydrochloride or 2-aminothiophenol or 2-aminophenol or benzene-1,2-diamine using μwave technique in aqueous media. All the synthesized compounds were evaluated for their anti-bacterial and antifungal activities. Some of the selected compounds were also screened for their anti-inflammatory activity. Keywords: Pyrazole, Isoxazole, Benzothiazepine, Benzoxazepine, Benzodiazepine, Anti-inflammatoryhttp://www.sciencedirect.com/science/article/pii/S1878535215000258
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Babasaheb V. Kendre Mahadev G. Landge Sudhakar R. Bhusare
spellingShingle	Babasaheb V. Kendre Mahadev G. Landge Sudhakar R. Bhusare Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents Arabian Journal of Chemistry
author_facet	Babasaheb V. Kendre Mahadev G. Landge Sudhakar R. Bhusare
author_sort	Babasaheb V. Kendre
title	Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents
title_short	Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents
title_full	Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents
title_fullStr	Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents
title_full_unstemmed	Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents
title_sort	synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents
publisher	Elsevier
series	Arabian Journal of Chemistry
issn	1878-5352
publishDate	2019-12-01
description	A new series of pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives were prepared by the multi-component cyclo-condensation reaction of 1-phenyl-3-(2-(tosyloxy)phenyl)propane-1,3-dione, N,N-dimethylformamide dimethyl acetal and hydrazine or hydroxylamine hydrochloride or 2-aminothiophenol or 2-aminophenol or benzene-1,2-diamine using μwave technique in aqueous media. All the synthesized compounds were evaluated for their anti-bacterial and antifungal activities. Some of the selected compounds were also screened for their anti-inflammatory activity. Keywords: Pyrazole, Isoxazole, Benzothiazepine, Benzoxazepine, Benzodiazepine, Anti-inflammatory
url	http://www.sciencedirect.com/science/article/pii/S1878535215000258
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Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents

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