The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37

Lymphocyte-specific protein tyrosine kinase (Lck) is a pivotal tyrosine kinase involved in T cell receptor (TCR) signaling. Because of its importance, the activity of Lck is regulated at different levels including phosphorylation of tyrosine residues, protein–protein interactions, and localization....

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Bibliographic Details
Main Authors: Sarah Kowallik, Andreas Kritikos, Matthias Kästle, Christoph Thurm, Burkhart Schraven, Luca Simeoni
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
Lck
Online Access:https://www.mdpi.com/1422-0067/22/1/126