G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts

G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts

G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses. As GPCRs can be activated by an extensive range of factors including hormones, neurotransmi...

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Bibliographic Details
Main Authors: Ernestina M. De Francesco, Federica Sotgia, Robert B. Clarke, Michael P. Lisanti, Marcello Maggiolini
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
GPCR
tumor angiogenesis
tumor microenvironment
VEGF
HIF-1
GPER
SDF-1
sphingosine-1P
Online Access:https://www.mdpi.com/1422-0067/18/12/2713

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