Gut Microbiota and Fecal Metabolome Perturbation in Children with Autism Spectrum Disorder
The brain-intestinal axis concept describes the communication between the intestinal microbiota as an ecosystem of a number of dynamic microorganisms and the brain. The composition of the microbial community of the human gut is important for human health by influencing the total metabolomic profile....
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| Format: | Article |
| Language: | English |
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Iranian Association of Gastroenterology and Hepatology, Shiraz University of Medical Sciences
2018-10-01
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| Series: | Middle East Journal of Digestive Diseases |
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| Online Access: | http://www.mejdd.org/index.php/mejdd/article/view/2039 |
| Summary: | The brain-intestinal axis concept describes the communication between the intestinal microbiota as an ecosystem of a number of dynamic microorganisms and the brain. The composition of the microbial community of the human gut is important for human health by influencing the total metabolomic profile. In children with autism spectrum disorder (ASD), the composition of the fecal microbiota and their metabolic products has a different configuration of the healthy child. An imbalance in the metabolite derived from the microbiota in children with ASD affect brain development and social behavior. In this article, we review recent discoveries about intestinal metabolites derived from microbiota based on high-yield molecular studies in children with ASD as part of the “intestinal brain axis”. |
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| ISSN: | 2008-5230 2008-5249 |