Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders.

Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders.

Polyclonal Epstein-Barr virus (EBV)-infected B cell line (lymphoblastoid cell lines; LCL)-stimulated T-cell preparations have been successfully used to treat EBV-positive post-transplant lymphoproliferative disorders (PTLD) in transplant recipients, but function and specificity of the CD4+ component...

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Bibliographic Details
Main Authors: Stefanie Linnerbauer, Uta Behrends, Dinesh Adhikary, Klaus Witter, Georg W Bornkamm, Josef Mautner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4031221?pdf=render

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http://europepmc.org/articles/PMC4031221?pdf=render

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