Measuring protein stability in the GroEL chaperonin cage reveals massive destabilization

Measuring protein stability in the GroEL chaperonin cage reveals massive destabilization

The thermodynamics of protein folding in bulk solution have been thoroughly investigated for decades. By contrast, measurements of protein substrate stability inside the GroEL/ES chaperonin cage have not been reported. Such measurements require stable encapsulation, that is no escape of the substrat...

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Bibliographic Details
Main Authors: Ilia Korobko, Hisham Mazal, Gilad Haran, Amnon Horovitz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
chaperones
protein folding
protein stability
Online Access:https://elifesciences.org/articles/56511

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