Catalytic asymmetric Catellani-type reaction: A powerful tool for axial chirality construction

• Main Authors: Yue Dong, Renshuai Liu, Wei Wang
• Format: Article
• Language: English
• Published: KeAi Communications Co. Ltd. 2020-11-01
• Series: Green Synthesis and Catalysis
• Subjects: Axially chiral biaryls; Asymmetric Catellani reaction; C–H functionalization; Cross coupling; Divergent synthesis
• Online Access: http://www.sciencedirect.com/science/article/pii/S2666554920300296
• ISSN: 2666-5549

This highlight summarizes a recent development of a catalytic enantioselective Catellani-type reaction for the synthesis of axially chiral biaryls. The chirality induction is solely governed by chiral norbornene ligand in the Pd mediated ortho C–H functionalization and ipso cross-coupling transformation. The preparative power of the methodology is demonstrated as a powerful manifold for the divergent synthesis of structurally diverse axially chiral biaryls and chiral fluorenols.