Preventative Effect of Mebendazole against Malignancies in Neurofibromatosis 1

Preventative Effect of Mebendazole against Malignancies in Neurofibromatosis 1

Patients with RASopathy Neurofibromatosis 1 (NF1) are at a markedly increased risk of the development of benign and malignant tumors. Malignant tumors are often recalcitrant to treatments and associated with poor survival; however, no chemopreventative strategies currently exist. We thus evaluated t...

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Bibliographic Details
Main Authors: Verena Staedtke, Tyler Gray-Bethke, Gregory J. Riggins, Ren-Yuan Bai
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Genes
Subjects:
neurofibromatosis 1 (NF1)
mebendazole (MBZ)
COX-2 inhibitor
MPNST
malignancy
sarcoma
Online Access:https://www.mdpi.com/2073-4425/11/7/762

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