An Optimized Treatment Protocol for Subretinal Injections Limits Intravitreal Vector Distribution

An Optimized Treatment Protocol for Subretinal Injections Limits Intravitreal Vector Distribution

Purpose: Subretinal injections (SRis) are commonly used in retinal gene therapy procedures to deliver adeno-associated virus (AAV) to photoreceptors and retinal pigment epithelial cells. We present an optimized surgical protocol to minimize off-target application of AAV in the vitreous, which in tur...

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Bibliographic Details
Main Authors: Felix F.L. Reichel, MD, Fabian Wozar, MD, Immanuel Seitz, MD, Alex Ochakovski, MD, K. Ulrich Bartz-Schmidt, MD, Tobias Peters, MD, M. Dominik Fischer, MD, PhD
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Ophthalmology Science
Subjects:
AAV
Gene therapy
Retina
Subretinal surgery
Viral vector
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914521000488

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