Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy

Time- and sex-dependent efficacy of magnesium sulfate to prevent behavioral impairments and cerebral damage in a mouse model of cerebral palsy

Cerebral lesions acquired in the perinatal period can induce cerebral palsy (CP), a multifactorial pathology leading to lifelong motor and cognitive deficits. Several risk factors, including perinatal hypoxia-ischemia (HI), can contribute to the emergence of CP in preterm infants. Currently, there i...

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Bibliographic Details
Main Authors: Ismaël Daher, Bérénice Le Dieu-Lugon, Maryline Lecointre, Nicolas Dupré, Caroline Voisin, Philippe Leroux, Nathalie Dourmap, Bruno J. Gonzalez, Stéphane Marret, Isabelle Leroux-Nicollet, Carine Cleren
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Neurobiology of Disease
Subjects:
Hypoxic-ischemic lesion
Magnesium sulfate
Sensorimotor behavior
Sex
Inflammation
Cognition
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118305126

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