Human umbilical cord mesenchymal stem cells reduce oxidative damage and apoptosis in diabetic nephropathy by activating Nrf2

Human umbilical cord mesenchymal stem cells reduce oxidative damage and apoptosis in diabetic nephropathy by activating Nrf2

Abstract Background Mesenchymal stem cells (MSCs) have a therapeutic effect on diabetic nephropathy (DN) but the underlying mechanism remains unclear. This study was conducted to investigate whether human umbilical cord-MSCs (hUCMSCs) can induce oxidative damage and apoptosis by activating Nrf2. Met...

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Bibliographic Details
Main Authors: Ping Nie, Xue Bai, Yan Lou, Yuexin Zhu, Shan Jiang, Lina Zhang, Na Tian, Ping Luo, Bing Li
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell
Oxidative damage
Apoptosis
Diabetic nephropathy
Nrf2
Online Access:https://doi.org/10.1186/s13287-021-02447-x

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