| Summary: | Background: Brain stimulation motor-evoked potentials (MEPs) are transient signals and not periodic signals, and thus, they differ significantly in their properties from classical surface electromyograms. Unsuitable pre-processing of MEPs due to inappropriate filter settings leads to distortions. Filtering of extensor carpi radialis MEPs with transient signal characteristics of 20 subjects was examined. The effects of a 1st-order Butterworth high-pass filter (HPF) with different cut-off frequencies 1 Hz, 20 Hz, 40 Hz, and 80 Hz and a 5 Hz Butterworth high-pass filter with degrees 1st, 2nd, 4th, 8th-order are investigated for the filter output. Results: The filtering of the MEPs with an inappropriate filter setting led to distortions on the parameters peak-to-peak amplitudes of the MEP (MEP<sub>pp</sub>) and the absolute integral of the MEP (MEP<sub>area</sub>). The lowest distortions of all of the examined filter parameters were revealed after filtering with the lowest filter order and the lowest cut-off frequency. The 1st-order 1 Hz HPF calculation results in a difference of −0.53% (<i>p</i> < 0.001) for the MEPpp and −1.94% (<i>p</i> < 0.001) for the MEParea. Significance: Reproducibility is a major concern in science, including brain stimulation research. Only the filtering of the MEPs with appropriate filter settings led to mostly undistorted MEPs.
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