Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation

The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside...

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Main Authors: Corina Danciu, Codruta Soica, Cristina Dehelean, Istvan Zupko, Erzsebet Csanyi, Iulia Pinzaru
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.1155/2015/262930
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spelling doaj-58aa355df273480ca1fd868ceb20bdbe2021-07-02T06:14:09ZengHindawi LimitedAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/262930262930Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin EncapsulationCorina Danciu0Codruta Soica1Cristina Dehelean2Istvan Zupko3Erzsebet Csanyi4Iulia Pinzaru5Department of Pharmacognosy, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of Pharmaceutical Chemistry, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of Toxicology, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, Eotvos utca 6, Szeged 6720, HungaryDepartment of Pharmaceutical Technology, University of Szeged, Dómtér 8., Szeged 6720, HungaryDepartment of Toxicology, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaThe present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.http://dx.doi.org/10.1155/2015/262930
collection DOAJ
language English
format Article
sources DOAJ
author Corina Danciu
Codruta Soica
Cristina Dehelean
Istvan Zupko
Erzsebet Csanyi
Iulia Pinzaru
spellingShingle Corina Danciu
Codruta Soica
Cristina Dehelean
Istvan Zupko
Erzsebet Csanyi
Iulia Pinzaru
Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
Analytical Cellular Pathology
author_facet Corina Danciu
Codruta Soica
Cristina Dehelean
Istvan Zupko
Erzsebet Csanyi
Iulia Pinzaru
author_sort Corina Danciu
title Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_short Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_full Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_fullStr Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_full_unstemmed Preliminary In Vitro Evaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation
title_sort preliminary in vitro evaluation of genistein chemopreventive capacity as a result of esterification and cyclodextrin encapsulation
publisher Hindawi Limited
series Analytical Cellular Pathology
issn 2210-7177
2210-7185
publishDate 2015-01-01
description The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measured in vitro on three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). The in vitro biological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines, behavior that may be due to the high stability of the complex within the in vitro environment.
url http://dx.doi.org/10.1155/2015/262930
work_keys_str_mv AT corinadanciu preliminaryinvitroevaluationofgenisteinchemopreventivecapacityasaresultofesterificationandcyclodextrinencapsulation
AT codrutasoica preliminaryinvitroevaluationofgenisteinchemopreventivecapacityasaresultofesterificationandcyclodextrinencapsulation
AT cristinadehelean preliminaryinvitroevaluationofgenisteinchemopreventivecapacityasaresultofesterificationandcyclodextrinencapsulation
AT istvanzupko preliminaryinvitroevaluationofgenisteinchemopreventivecapacityasaresultofesterificationandcyclodextrinencapsulation
AT erzsebetcsanyi preliminaryinvitroevaluationofgenisteinchemopreventivecapacityasaresultofesterificationandcyclodextrinencapsulation
AT iuliapinzaru preliminaryinvitroevaluationofgenisteinchemopreventivecapacityasaresultofesterificationandcyclodextrinencapsulation
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