Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein

Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein

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The Crimean–Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFV as a priority pathogen with an urgent need for enhanced research activities to develop effective countermeasures. We rep...

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Bibliographic Details
Main Authors: Egor P. Tchesnokov, Ben A. Bailey-Elkin, Brian L. Mark, Matthias Götte
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Proceedings
Subjects:
RNA-dependent RNA polymerase
deubiquitinase
viral replication
Online Access:https://www.mdpi.com/2504-3900/50/1/41

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