Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin

Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin

Malignant mesothelioma (MM) is an aggressive asbestos-linked neoplasm, characterized by dysregulation of signaling pathways. Due to intrinsic or acquired chemoresistance, MM treatment options remain limited. Calretinin is a Ca<sup>2+</sup>-binding protein expressed during MM tumorigenesi...

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Bibliographic Details
Main Authors: Janine Wörthmüller, Valérie Salicio, Anne Oberson, Walter Blum, Beat Schwaller
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
malignant mesothelioma
iptg-inducible system
calretinin
fak signaling
wnt signaling
chemoresistance
cisplatin
Online Access:https://www.mdpi.com/1422-0067/20/21/5391

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