Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma

Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma

Accumulating evidence suggests that extracellular signal-regulated kinase (ERK) is a valuable target molecule for cancer. However, antitumor drugs targeting ERK are still in their clinical phase and no FDA-approved medications exist. In this study, we identified an ERK inhibitor (ERKi; Vx-11e) with...

Full description

Bibliographic Details
Main Authors: Man Zhang, Yang Bai, Chang Xu, Yiying Qi, Jiahong Meng, Wenkan Zhang, Hang Su, Weiqi Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ERK
transcription factor EB
autophagy
osteosarcoma
energy metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.650846/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.650846/full

Similar Items