Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody

Uterine and ovarian carcinosarcomas overexpressing Trop-2 are sensitive to hRS7, a humanized anti-Trop-2 antibody

<p>Abstract</p> <p>Background</p> <p>We evaluated the expression of human trophoblastic cell-surface marker (Trop-2) and the potential of hRS7 - a humanized monoclonal anti-Trop-2 antibody - as a therapeutic strategy against treatment-refractory human uterine (UMMT) and...

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Bibliographic Details
Main Authors: Raji Rhoda, Guzzo Federica, Carrara Luisa, Varughese Joyce, Cocco Emiliano, Bellone Stefania, Betti Marta, Todeschini Paola, Gasparrini Sara, Ratner Elena, Silasi Dan-Arin, Azodi Masoud, Schwartz Peter, Rutherford Thomas J, Buza Natalia, Pecorelli Sergio, Santin Alessandro D
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
carcinosarcoma
hRS7
immunotherapy
natural killer cell
Trop-2
Online Access:http://www.jeccr.com/content/30/1/106

Internet

http://www.jeccr.com/content/30/1/106

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