Competitive interactions of ligands and macromolecular crowders with maltose binding protein.

Cellular signaling involves a cascade of recognition events occurring in a complex environment with high concentrations of proteins, polysaccharides, and other macromolecules. The influence of macromolecular crowders on protein binding affinity through hard-core repulsion is well studied, and possib...

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Bibliographic Details
Main Authors: Andrew C Miklos, Matthew Sumpter, Huan-Xiang Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24124463/pdf/?tool=EBI