NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

NACK and INTEGRATOR act coordinately to activate Notch-mediated transcription in tumorigenesis

Abstract Background Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Complex Kinase (NACK), INT activates Notch1 target genes by driving RNA poly...

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Bibliographic Details
Main Authors: Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J. Robbins, Ramin Shiekhattar, Anthony J. Capobianco
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cell Communication and Signaling
Subjects:
Notch signaling
NACK
Integrator
Esophageal adenocarcinoma
Tumorigenesis
Transcriptional activation
Online Access:https://doi.org/10.1186/s12964-021-00776-1

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