Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2

Ornithine decarboxylase (ODC) is the key enzyme in the polyamine biosynthetic pathway. ODC levels are controlled by polyamines through the induction of antizymes (AZs), small proteins that inhibit ODC and target it to proteasomal degradation without ubiquitination. Antizyme inhibitors (AZIN1 and AZI...

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Bibliographic Details
Main Authors: Bruno Ramos-Molina, Ana Lambertos, Andrés J. Lopez-Contreras, Joanna M. Kasprzak, Anna Czerwoniec, Janusz M. Bujnicki, Asunción Cremades, Rafael Peñafiel
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Antizyme
Antizyme-binding element
Homology modeling
Polyamines
Protein degradation
Proteasome inhibitors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000527

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