A brief overview of antitumoral actions of bruceine D

Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that decrease the quality of patient’s lives. As such, natural bi...

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Main Authors:	Zi Wayne Sin, Vipul Bhardwaj, Amit Kumar Pandey, Manoj Garg
Format:	Article
Language:	English
Published:	Open Exploration Publishing Inc. 2020-08-01
Series:	Exploration of Targeted Anti-tumor Therapy
Subjects:	cancer bruceine d epithelial-to-mesenchymal transition cancer stem cells metastasis apoptosis anti-inflammatory pi3k/akt/erk pathway introd
Online Access:	https://www.explorationpub.com/Journals/etat/Article/100213

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spelling	doaj-5869a49408124779b0d9cbbb506de4ec2021-04-07T05:18:18ZengOpen Exploration Publishing Inc.Exploration of Targeted Anti-tumor Therapy2692-31142020-08-011420021710.37349/etat.2020.00013A brief overview of antitumoral actions of bruceine DZi Wayne Sin0Vipul Bhardwaj1Amit Kumar Pandey2Manoj Garg3Department of Biological Sciences, National University of Singapore, Singapore 117600, SingaporeAmity Institute of Molecular Medicine and Stem cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida 201313, IndiaAmity Institute of Biotechnology, Amity University Haryana, Manesar, Haryana 122413, IndiaAmity Institute of Molecular Medicine and Stem cell Research (AIMMSCR), Amity University Uttar Pradesh, Noida 201313, IndiaCancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that decrease the quality of patient’s lives. As such, natural bioactive compounds have gained an attraction in the scientific and medical community as evidence of their anticancer properties and attenuation of side effects mounted. In particular, quassinoids have been found to exhibit a plethora of inhibitory activities such as anti-proliferative effects on tumor development and metastasis. Recently, bruceine D, a quassinoid isolated from the shrub Brucea javanica (L.) Merr. (Simaroubaceae), has come under immense investigation on its antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. In this review, we have highlighted the antineoplastic effects of bruceine D and its mode of actions in different tumor models.https://www.explorationpub.com/Journals/etat/Article/100213cancerbruceine depithelial-to-mesenchymal transitioncancer stem cellsmetastasisapoptosisanti-inflammatorypi3k/akt/erk pathway introd
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zi Wayne Sin Vipul Bhardwaj Amit Kumar Pandey Manoj Garg
spellingShingle	Zi Wayne Sin Vipul Bhardwaj Amit Kumar Pandey Manoj Garg A brief overview of antitumoral actions of bruceine D Exploration of Targeted Anti-tumor Therapy cancer bruceine d epithelial-to-mesenchymal transition cancer stem cells metastasis apoptosis anti-inflammatory pi3k/akt/erk pathway introd
author_facet	Zi Wayne Sin Vipul Bhardwaj Amit Kumar Pandey Manoj Garg
author_sort	Zi Wayne Sin
title	A brief overview of antitumoral actions of bruceine D
title_short	A brief overview of antitumoral actions of bruceine D
title_full	A brief overview of antitumoral actions of bruceine D
title_fullStr	A brief overview of antitumoral actions of bruceine D
title_full_unstemmed	A brief overview of antitumoral actions of bruceine D
title_sort	brief overview of antitumoral actions of bruceine d
publisher	Open Exploration Publishing Inc.
series	Exploration of Targeted Anti-tumor Therapy
issn	2692-3114
publishDate	2020-08-01
description	Cancer remains the second leading cause of mortality globally. In combating cancer, conventional chemotherapy and/or radiotherapy are administered as first-line therapy. However, these are usually accompanied with adverse side effects that decrease the quality of patient’s lives. As such, natural bioactive compounds have gained an attraction in the scientific and medical community as evidence of their anticancer properties and attenuation of side effects mounted. In particular, quassinoids have been found to exhibit a plethora of inhibitory activities such as anti-proliferative effects on tumor development and metastasis. Recently, bruceine D, a quassinoid isolated from the shrub Brucea javanica (L.) Merr. (Simaroubaceae), has come under immense investigation on its antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. In this review, we have highlighted the antineoplastic effects of bruceine D and its mode of actions in different tumor models.
topic	cancer bruceine d epithelial-to-mesenchymal transition cancer stem cells metastasis apoptosis anti-inflammatory pi3k/akt/erk pathway introd
url	https://www.explorationpub.com/Journals/etat/Article/100213
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A brief overview of antitumoral actions of bruceine D

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