Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss

Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss

Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The anti...

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Main Authors: Véronique Piroux, Valérie Eschwège, Jean-Marie Freyssinet
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Infectious Diseases in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/S1064744997000264
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spelling doaj-586716c7ce5246168da0073b4e42d2bd2020-11-24T22:57:34ZengHindawi LimitedInfectious Diseases in Obstetrics and Gynecology1064-74491098-09971997-01-015217618010.1155/S1064744997000264Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy LossVéronique Piroux0Valérie Eschwège1Jean-Marie Freyssinet2Institut d'Hématologie et d'Immunologie, Faculté de Médecine, Université Louis Pasteur, 4, rue Kirschleger, Strasbourg 67085, FranceUnité 143 INSERM, Hôpital de Bicêtre, Le Kremlin-Bicêtre, FranceInstitut d'Hématologie et d'Immunologie, Faculté de Médecine, Université Louis Pasteur, 4, rue Kirschleger, Strasbourg 67085, FranceAntiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.http://dx.doi.org/10.1155/S1064744997000264
collection DOAJ
language English
format Article
sources DOAJ
author Véronique Piroux
Valérie Eschwège
Jean-Marie Freyssinet
spellingShingle Véronique Piroux
Valérie Eschwège
Jean-Marie Freyssinet
Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
Infectious Diseases in Obstetrics and Gynecology
author_facet Véronique Piroux
Valérie Eschwège
Jean-Marie Freyssinet
author_sort Véronique Piroux
title Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
title_short Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
title_full Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
title_fullStr Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
title_full_unstemmed Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss
title_sort cell damage at the origin of antiphospholipid antibodies and their pathogenic potential in recurrent pregnancy loss
publisher Hindawi Limited
series Infectious Diseases in Obstetrics and Gynecology
issn 1064-7449
1098-0997
publishDate 1997-01-01
description Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.
url http://dx.doi.org/10.1155/S1064744997000264
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AT jeanmariefreyssinet celldamageattheoriginofantiphospholipidantibodiesandtheirpathogenicpotentialinrecurrentpregnancyloss
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