Cell Damage at the Origin of Antiphospholipid Antibodies and Their Pathogenic Potential in Recurrent Pregnancy Loss

Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The anti...

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Bibliographic Details
Main Authors: Véronique Piroux, Valérie Eschwège, Jean-Marie Freyssinet
Format: Article
Language:English
Published: Hindawi Limited 1997-01-01
Series:Infectious Diseases in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/S1064744997000264
Description
Summary:Antiphospholipid antibodies (APA) are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.
ISSN:1064-7449
1098-0997