An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo

An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo

The mRNA-based vaccine approach is a promising alternative to traditional vaccines due to its ability for prompt development, high potency, and potential for secure administration and low-cost production. Nonetheless, the application has still been limited by the instability as well as the ineffecti...

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Bibliographic Details
Main Authors: Md. Motiar Rahman, Nan Zhou, Jiandong Huang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
IVT mRNA
mRNA vaccine
electroporation
protamine
LNPs
Online Access:https://www.mdpi.com/2076-393X/9/3/244
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spelling doaj-58663ef338fa47ee8e08d2bddc1720782021-03-12T00:00:22ZengMDPI AGVaccines2076-393X2021-03-01924424410.3390/vaccines9030244An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In VivoMd. Motiar Rahman0Nan Zhou1Jiandong Huang2Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaInstitute of Synthetic Biology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaInstitute of Synthetic Biology, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen 518055, ChinaThe mRNA-based vaccine approach is a promising alternative to traditional vaccines due to its ability for prompt development, high potency, and potential for secure administration and low-cost production. Nonetheless, the application has still been limited by the instability as well as the ineffective delivery of mRNA in vivo. Current technological improvements have now mostly overcome these concerns, and manifold mRNA vaccine plans against various forms of malignancies and infectious ailments have reported inspiring outcomes in both humans and animal models. This article summarizes recent mRNA-based vaccine developments, advances of in vivo mRNA deliveries, reflects challenges and safety concerns, and future perspectives, in developing the mRNA vaccine platform for extensive therapeutic use.https://www.mdpi.com/2076-393X/9/3/244IVT mRNAmRNA vaccineelectroporationprotamineLNPs
collection DOAJ
language English
format Article
sources DOAJ
author Md. Motiar Rahman
Nan Zhou
Jiandong Huang
spellingShingle Md. Motiar Rahman
Nan Zhou
Jiandong Huang
An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo
Vaccines
IVT mRNA
mRNA vaccine
electroporation
protamine
LNPs
author_facet Md. Motiar Rahman
Nan Zhou
Jiandong Huang
author_sort Md. Motiar Rahman
title An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo
title_short An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo
title_full An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo
title_fullStr An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo
title_full_unstemmed An Overview on the Development of mRNA-Based Vaccines and Their Formulation Strategies for Improved Antigen Expression In Vivo
title_sort overview on the development of mrna-based vaccines and their formulation strategies for improved antigen expression in vivo
publisher MDPI AG
series Vaccines
issn 2076-393X
publishDate 2021-03-01
description The mRNA-based vaccine approach is a promising alternative to traditional vaccines due to its ability for prompt development, high potency, and potential for secure administration and low-cost production. Nonetheless, the application has still been limited by the instability as well as the ineffective delivery of mRNA in vivo. Current technological improvements have now mostly overcome these concerns, and manifold mRNA vaccine plans against various forms of malignancies and infectious ailments have reported inspiring outcomes in both humans and animal models. This article summarizes recent mRNA-based vaccine developments, advances of in vivo mRNA deliveries, reflects challenges and safety concerns, and future perspectives, in developing the mRNA vaccine platform for extensive therapeutic use.
topic IVT mRNA
mRNA vaccine
electroporation
protamine
LNPs
url https://www.mdpi.com/2076-393X/9/3/244
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