A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations

A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations

Summary: Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disorder of heart muscle thickening associated with sudden cardiac death and heart failure, with unclear mechanisms. We engineered four isogenic induced pluripotent stem cell (iPSC) models of β-myo...

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Bibliographic Details
Main Authors:	Rachel Cohn, Ketan Thakar, Andre Lowe, Feria A. Ladha, Anthony M. Pettinato, Robert Romano, Emily Meredith, Yu-Sheng Chen, Katherine Atamanuk, Bryan D. Huey, J. Travis Hinson
Format:	Article
Language:	English
Published:	Elsevier 2019-01-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671118304831

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