Inhibition of ERK 1/2 kinases prevents tendon matrix breakdown

Inhibition of ERK 1/2 kinases prevents tendon matrix breakdown

Abstract Tendon extracellular matrix (ECM) mechanical unloading results in tissue degradation and breakdown, with niche-dependent cellular stress directing proteolytic degradation of tendon. Here, we show that the extracellular-signal regulated kinase (ERK) pathway is central in tendon degradation o...

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Bibliographic Details
Main Authors: Ulrich Blache, Stefania L. Wunderli, Amro A. Hussien, Tino Stauber, Gabriel Flückiger, Maja Bollhalder, Barbara Niederöst, Sandro F. Fucentese, Jess G. Snedeker
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85331-1

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