The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China

The impact of combined gene mutations in inhA and ahpC genes on high levels of isoniazid resistance amongst katG non-315 in multidrug-resistant tuberculosis isolates from China

Abstract Whole-genome sequencing was used to analyze the profiles of isoniazid (INH) resistance-related mutations among 188 multidrug-resistant strains of Mycobacterium tuberculosis (MDR-TB) and mono-INH-resistant isolates collected in a recent Chinese national survey. Mutations were detected in 18...

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Bibliographic Details
Main Authors: Liguo Liu, Fengting Jiang, Lihong Chen, Bing Zhao, Jie Dong, Lilian Sun, Yafang Zhu, Bo Liu, Yang Zhou, Jian Yang, Yanlin Zhao, Qi Jin, Xiaobing Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-11-01
Series:Emerging Microbes and Infections
Online Access:http://link.springer.com/article/10.1038/s41426-018-0184-0

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